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The amount of earthwork operations depends on the design of the vertical alignment, so a good vertical alignment can have a profound impact on final construction costs.
This is to be expected, as the radius used for feature atoms in CT computations is nearly 60% smaller than for carbon atoms, meaning small changes in the alignment can have a big effect on similarity, especially for features that are furthest from the steric center (a "torque arm" effect).
The quality of a multiple sequence alignment can have a strong impact on the accuracy of the inferred phylogenetic tree, whatever the inference criterion used [ 1- 4].
Differences in student thinking and their accuracy of alignment can have important implications for learning, including characterizing the relationship between what content students know, what content they accurately recognize knowing, and how accuracy may be developed.
In addition to the annotations adopted in this study, customized annotations can also be included in the output e.g., the pairwise sequence alignment can have annotations for residues interacting with biomolecular partner(s).
Splign can report both sense and anti-sense alignments for a single mRNA which may give it an advantage over the tools that report alignments in one direction, because an incorrectly directed alignment can have an identity higher than the one in the correct direction.
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In general, we found that multiple alignments can have a large influence on OTU abundance information, and the automated 16S rRNA alignment tools should be subjected to hand curation.
However, gene trees estimated on short alignments can have high estimation error, and summary methods tend to have high error on short c-genes.
The quality of multiple sequence alignments can have a dramatic impact on the accuracy of the phylogenies produced [e.g., [ 31- 33]].
Our multiple analysis approach shows that alignment ambiguities can have a significant impact on branch support obtained by analysis of ITS sequences in Microbotryum, a factor which, as in many molecular phylogenetic analyses, has not been investigated so far.
The designed dyes are found to exhibit wide absorption spectra, high molar extinction coefficients, desirable orbital distributions, and good energy levels alignment, and hence can have potential applications in dye-sensitized solar cells.
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