The phrase "alignment and conservation" is correct and usable in written English.
It can be used in contexts related to ecology, biology, or any field discussing the coordination of efforts to maintain or protect resources or systems.
Example: "The project focuses on the alignment and conservation of natural habitats to ensure biodiversity."
Alternatives: "coordination and preservation" or "synchronization and protection".
Miller, W. et al. 28-way vertebrate alignment and conservation track in the UCSC Genome Browser.
Sequence alignment and conservation of the SNPs were analysed by EMBL-EBI and Polyphen.
As is evident from the Figure 3A, sequence conservation of the SLC6A3 locus across phylogenies at most is very limited: Sparse conserved elements are confined to coding sequences whilst the regulatory regions, including promoter, introns and 3'-UTR do not exhibit conservation (Vertebrate Multiz Alignment and Conservation, 44 species).
An alignment and conservation analysis of human and mouse sequences focusing on the VE-statin/egfl7 gene regions located ahead of the transcription starts -1a and -1b showed the presence of several well-conserved regions, noted A to E (Figure S3).
These were manually inspected for splice site, alignment and conservation validity, resulting in 40 regions comprising 41 NIPs.
Next, we qualitatively assessed the degree of conservation of each of these clones using the Vertebrate and Multiz Alignment and Conservation track at UCSC [ 20].
To eliminate the possibility that the patterns of non-coding conservation might be due to the different parameters used in computing alignments and conservation, we realigned and reanalyzed the Drosophila genomes and our tephritid sequence, as well as one percent of the human genome, using a set programs and parameters equivalent to the UCSC alignment and analysis pipeline.
However, a more thorough sequence conservation analysis, involving comprehensive alignments and conservation measurements, has the potential to be much more powerful.
Such analyses are not dependent on alignments and conservation and are themselves strong independent confirmation of the results based on conservation.
Approaches such as the number of initial equivalences [Additional file 3: Figure S1], number of secondary structural equivalences (SST) and root mean square deviation (RMSD) of structural entries were used to assess the alignment quality and conservation of length and substructures (Table 1).
Sequence comparison of miRNAs among species was performed through the University of California Santa Cruise Genome Browser (Kent et al, 2002), using the Vertebrate Multiz Alignment and PhastCons Conservation (multiple alignments of 28 vertebrate species and two measures of evolutionary conservation).
