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Structural and sequence alignment analyses have revealed the existence of class-dependent and -independent local motifs involved in the overall fold of the ligand-binding domain (LBD) in the nuclear receptor (NR) superfamily.
Here, by sequence alignment analyses of the human KCNQ1 channel and scorpion potassium channel MmKv2, which is completely insensitive to scorpion toxins, we proposed that the insensitivity mechanism of KCNQ1 toward natural scorpion toxins might involve two functional regions, the turret and filter regions.
Based on BLAST and alignment analyses, the CHD-Z and CHD-W sequences of nine species of eagles were highly homologous with Spilornis cheela hoya (S. c. hoya); therefore, TaqMan probes were designed to target their CHD-ZW-common and CHD-W-specific regions.
Open image in new window Figure 1 Phylogeny of Boxer virus among GI NoVs and sequence alignment analyses.
His research focuses on assessment and its implications in science education, including applications of Rasch measurement models and alignment analyses for assessments and standards.
amplicon was compared with Genebank accession X16293 sequence for MAP IS900 using BLAST (NLM) and sequence alignment analyses.
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The alignment used in the BEAST analysis was a reduced version of the alignment analysed with MrBayes, as we did not include a published ancient undated sample (see Supplementary Table 3).
To investigate the RNA features required for XBP1 mRNA splicing, we performed multiple-sequence-alignment analyses of RNA segments adjacent to the splice sites from evolutionarily distant metazoans (Figs 1A and EV1A).
This result is comparable to culled-alignment analyses of SSU rDNA, 3, 10 the only two other studies that used data of all nonspinose taxa that were available at that time.
SJM carried out the sequence alignments, analyses and wrote the manuscript.
For all sub-optimal alignments analysed in our study, the detection of the fail-safe repeats never dropped below 46 (out of 50) for HEAT repeats, and never below 39 (out of 41) for ARM repeats.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com