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Once nodes are aligned, the function of a protein or gene whose role is unknown can be predicted, if the function of its matched node in the other network is known.
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As a first step in aligning the functions of the DBD with the Essential Services of Public Health, the DBD assessed the epidemiology of blood disorders occurrence rates, characteristics of the conditions, associated morbidities, and risk profiles of people affected by them.
Two general linear models were calculated with different time points for aligning the hemodynamic response function.
Here, b l is the peak scaling function and w(n) represents the aligned pulse cancellation function at the position l.
Further supporting this model, the components of NNP triplets show highly correlated epistatic interaction profiles within the triplet (Spearman correlation 0.79 ± 0.07 and 0.23 ± 0.08 for the positively and negatively interacting genes respectively), suggesting aligned function among the genes, and especially among the positively interacting genes.
The sequences were aligned by the ClustalW function in MEGA 4.0 software [ 35].
Insertion sites were aligned using the BLAT function of the UCSC Genome Browser version hg19 (http://genome.ucsc.edu/cgi-bin/hgGateway).
Electropherograms were checked manually, and the obtained sequences were aligned using the ClustalW function in Geneious 5.6.6 [ 74] (Biomatters, Auckland, New Zealand).
PDE4 translated amino acid sequences were aligned using the Clustal function of Mega v4, according to the default settings.
PKA-R translated amino acid sequences were aligned using the Clustal function of Mega v5 [ 59].
To align the density function and the boundary one would want to minimize.
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