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If the resultant moments of these domains are randomly oriented, the object as a whole will not display magnetism, but an externally applied magnetizing field will, depending on its strength, rotate one after another of the domains into alignment with the external field and cause aligned domains to grow at the expense of nonaligned ones.
Carbon nanotube gel dispersions used in this study have aligned domains and a low yield stress.
Based on the spatial alignment of known three-dimensional structures of immunoglobulin domains, it places the alignment gaps in a way that minimizes the average deviation from the averaged structure of the aligned domains.
Our laboratory has recently developed liquid crystalline solutions of peptide amphiphile nanofibers that form aligned domains at exceedingly low concentrations (<1wt%), and can be trapped as gels with macroscopic alignment using low shear rates and ionic crosslinking.
However, realignment has a cost; a fraction of correctly aligned domains are incompletely realigned.
SH3PepInt uses graph kernels on a complex representation of both the peptide sequence and the aligned domains.
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Phylogenetic NJ tree was also made using aligned domain sequences of both, rice and Arabidopsis together.
Structurally aligned domain pairs were selected from among the structurally superposed pairs, using the following criteria.
The gaps are placed to minimize the average deviation from the averaged structure of the aligned domain so that the position of the CDRs remains consistent.
Finally, we show how to build a model that takes in input both the peptide information and the (aligned) domain amino acid sequence.
At least one instance of an incorrectly aligned domain architecture in a LDL-A domain bearing GPCR was revealed (ci0100131758) after a BLAT of the sequence was performed against the Ciona genome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com