NIST evaluated our algorithm from submission data that was made using 44 hours of evaluation dataset.
For this analysis, we obtained SIFT and PolyPhen-2 predictions using the corresponding algorithms' batch submission facilities, whereas Mutation Assessor predictions were collected using the available web service, and SPF-Cancer predictions were provided by the corresponding author on request (as no batch submission is available).
The algorithm consists of initialization, submission, branching, collection, bounding, and pruning steps.
When it is announced next year, it will be the product of a public call for algorithms that resulted in 64 submissions from over a dozen countries and then years of international analysis.
Figure 9 shows only the gross effect of each processing scheme on the collection of results, which quite often does not reflect the effectiveness of a particular algorithm proposed in a certain submission.
Submissions from top diggers are more likely to get to the front page of Digg for 2 reasons: the algorithm weighs a top digger's submission more heavily, and a top Digger has a lot of friends on Digg who like to support each other by digging the same stories.
Since the validity of each particular algorithm is confirmed experimentally in each submission, we refer to the corresponding papers for a closer look at the effects of the algorithms and schemes.
Five revised and expanded papers were selected from the BIOKDD workshop, out of a total of 18 submissions, to appear in Algorithms for Molecular Biology (AMB).
A web-based implementation of our algorithm, including a high-throughput batch submission facility and a downloadable stand-alone package, is available at http://fathmm.biocompute.org.uk.uk
Many submissions utilized a 1-ch algorithm that models the convolutional effect of reverberation in the amplitude domain [17, 26, 29, 32, 43] and showed its efficacy.
