We found compelling variation in risk of hip fracture by type of alcohol preference, where women who preferred wine appeared to have the lowest risk of hip fracture.
We have also reported the involvement of cannabinoid CB2-Rs in alcohol preference in mice and alcoholism in humans [19], which supports the functional presence of neuronal CB2-Rs in the mammalian CNS.
Sardinian alcohol-preferring (sP) rats have been selectively bred for high alcohol preference and consumption.
More specifically, for the former, seven mutually exclusive categories of alcohol preference were created; non-drinker, past drinker, and current drinkers who prefer beer, wine, hard liquor, have no strong preference, or drink very infrequently, as determined by food frequency questionnaire (FFQ) consumption patterns of beer, wine, and hard liquor at baseline.
Data were analyzed for patients with high alcohol preference (HP) and low alcohol preference (LP) by dichotomizing the sample according to median alcohol intake prior to detoxification.
Clozapine attenuated the initiation of alcohol drinking and development of alcohol preference while haloperidol did not.
However, it is unknown which anatomical NPY systems are involved in alcohol preference.
In laboratory animals, however, the use of anxiety to predict alcohol preference has remained difficult.
In fact, an inverse relationship between density and metabolic functioning of regional brain 5-HT system and alcohol preference was repeatedly reported in animal studies [69 72].
These results of the selective breeding experiment suggest that brain region-specific differences in μ-opioid receptor function may correlate with innate differences in alcohol preference.
Certainly, if a less alcohol preference in migraine patients will be confirmed in large controlled studies, it merits a correlation with 5-HT system, which is involved in migraine pathogenesis in some way.
