When all sgRNAs targeting three genes were transfected, albeit in different ratios, we observed robust activation of all three genes.
However, when we relaxed the filters to obtain more (albeit lower quality) windows, we observed obvious peaks (high RRT values) for both histidine codons at position 6 specifically in the 3-aminotriazole experiment (data not shown).
If future studies validate the reduction in ADA3 expression that we observed, albeit in a small subset of breast cancers, it will be of considerable biological interest to assess if such tumors have an activation of alternate pathways that compensate for ADA3 functions.
When adding IL-12 to stimulations of iNKT cells by TRAMP-C2 cells, we observed significant albeit minimal levels of IFNγ produced by iNKT cells (Fig. 5B, bar 6).
Nevertheless, even after outcrosses to minimize genetic background differences between mutants and two different revertant strains (bearing excision chromosomes lacking the P element), we observed small, albeit statistically significant, effects of the E74BG01805 mutation on the activity rhythm.
We observed bone, albeit in small amounts, on porous coated surfaces of titanium.
We observed that, albeit the two crosses shared a common accession, the eQTL distribution among these types is very dissimilar.
We observed that, albeit an equivocal zone was observed, most grade 2 tumors could be separated in fMG 1-like and fMG 3-like.
We observed similar, albeit weaker, associations between DAP concentrations and neurobehavioral outcomes when we stratified results by maternal genotype rather than child genotype [Supplemental Material, Table 4 (doi:10.1289/ehp.1002234)].
Even for datasets with 1000 instances we observed slight albeit statistically significant increase in AUROC values (0.04) (whiskers in Fig. 2 mark 95% confidence intervals).
