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Albeit promiscuous in deubiquitinating cellular proteins, PLP2 inactivated TBK1 and IFN-β response in TNF receptor associated factor 3 (TRAF3) deficient cells, suggesting that targeting TBK1 would be sufficient for PLP2 to inhibit IRF3 activation.
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Goldstein is well placed to make this judgment, having been brought up in an ultra-orthodox Jewish household, albeit one that allowed promiscuous reading.
This suggests that the OP hydrolase activity of the OPAA family is simply a promiscuous activity, albeit a moderately efficient one, and that the major cellular role of these enzymes is as a prolidase.
Ligase-client interactions for membrane proteins may therefore be rather promiscuous and frequent, albeit relatively brief in most instances.
Other ARTs appear more promiscuous, e.g. mouse ART2, which ADP-ribosylates many proteins, albeit only at arginine residues (Fig. 2, lane 1).
Albeit flawed.
Visually, "John Carter" is promiscuous.
Christmas pop is promiscuous.
Olive is promiscuous.
Online is endemically promiscuous.
It is promiscuous.
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