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Albeit highly interesting in itself, knowledge of toxicity mechanisms impacts only slightly on policy making and regulatory action.
Albeit highly abstract at first sight, the applicability of Boolean GRNs, as well as derived conceptual implications, have been supported extensively both by experimental observations [ 5, 16, 17] and by theoretical GRNs grounded on experimental data [ 11, 18].
Albeit highly valuable, the models used in those studies were focused on genetic modification in target cells and did not allow for direct testing of the role of non-autonomous factors in the pathogenesis of cancers associated with BRCA1 deficiency.
Albeit highly speculative, this 'model' postulates an interaction between CD147, which is a transmembrane glycoprotein and a gamma-secretase subunit that is expressed by neuronal cells, and cyclophilin B, which is incorporated into the MeV surface.
Our extremely limited knowledge of the developmental genetic basis for sexual dimorphism in insects is largely restricted to Drosophila melanogaster, a genetically tractable —albeit highly derived —dipteran insect that exhibits innate sexually dimorphic behaviors.
Yet MIF has had only one, albeit highly successful, edition.
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Albeit, being highly cytotoxic to MRC-5 cells (CC50 0.45 μg/mL), compound 54 indicates a poor selectivity to normal cells.
Surprisingly, despite previous suggestions that ontogenetic changes in venom are prey-related [ 33], juvenile Dusky Pigmy rattlesnakes, Sistrurus miliarius barbouri, raised on different diets showed similar albeit highly-variable venom compositions by the end of a 26-months study, suggesting little effect of diet on the overall make-up of venom in snakes this age or younger [ 23].
What transpires is quite literally a wild goose chase, albeit a highly enjoyable one.
In a 2012 interview with the Observer, he came across as an everyman, albeit a highly sexed one.
A painting packing a punch is always a welcome find, and viewers might sense a fist, albeit a highly satisfying one, in "Memorial for a Haida Chief," by Sergio Gonzalez-Tornero.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com