Exact(1)
The fact that HD is an autosomal dominant disorder argues in favor of a gain of function of the protein, where mHtt is endowed with a novel, albeit deleterious function that is important to HD pathogenesis.
Similar(56)
The currently available data on hyperoxia (with consecutive hyperoxemia) during ischemic brain injury, i.e., stroke and/or intracranial bleeding, is less conflicting: Albeit there is compelling experimental evidence (for review, see [130]) and some encouraging pilot data in patients [131, 132], evidence from large trials suggests that hyperox em)ia is deleterious.
Most of the mutations will be deleterious.
It evokes unpleasant images, and is always deleterious.
The currently available data on hyperoxia (with consecutive hyperoxemia) during ischemic brain injury, i.e., stroke and/or intracranial bleeding, is less conflicting: Albeit there is compelling experimental evidence (for review, see [ 130]) and some encouraging pilot data in patients [ 131, 132], evidence from large trials suggests that hyperox em)ia is deleterious.
This supports, albeit indirectly, a deleterious effect of mutations in these regions of the protein.
An even more deleterious, albeit less probable, event might be an accidental escape of an experimental vector that harbors an oncogenic "cargo".
Yet, a portion of risk alleles may be regarded as deleterious, albeit mildly, from a medical standpoint but evolutionary neutral or even beneficial.
However, it remains elusive whether the apoE2 isoform exerts truly protective effect against Aβ pathology or apoE2 plays deleterious role albeit less pronounced than the apoE4 isoform.
However, it remains unclear whether the effect of apoE2 on Aβ pathology is truly protective, or whether apoE2 merely plays deleterious role albeit less pronounced than that of apoE4.
Others have argued that in strains of S. cerevisiae isolated from their natural habitat, both the [PSI+] and [URE3] prions may have had a net deleterious effect on cell reproduction which, albeit subtle, leads to a failure to find wild strains containing these prions [33], [34].
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