A timescale of hours rather than days now places activity-dependent AIS change squarely within the time frame occupied by many other forms of neuronal plasticity, particularly those involving structural alterations (Keck et al., 2011, Lei et al., 2006, Nägerl et al., 2004, Rocha and Sur, 1995, Sin et al., 2002, Yamahachi et al., 2009, Yu et al., 2011).
Indeed, pro-PKA treatment did not significantly change AIS length, but it did reverse the depolarization-induced changes in NaV channel properties.
We felt this better represented the data prior to 2005 and post 2005 AIS coding changes and therefore improved reliability of our data.
Furthermore, the ISS depends on the AIS codebook, which repeatedly had been changed and updated.
In adolescents with idiopathic scoliosis (AIS), several studies have shown that the pelvis is structurally changed by the spinal disorder.
Thus, proteins that are allocated to the AIS, such as ankyrinG, change their distribution along the axon after HDAC6 inhibition or suppression, allowing other ankyrinG interacting proteins, such as voltage gated sodium channels to diffuse along the axon.
As treatments may change the natural history of AIS, patients who had received any previous treatment were initially excluded from the case-only study.
In addition, it might change the ability of the AIS to increase either its length or its distance from the soma as a way for the neuron to adapt its excitability in response to changes in neuronal activity [ 3, 4].
Although Milwaukee brace leads to significant decreased TK in AIS patients, the change of TK is small.
