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The third-generation AIs approved by the Food and Drug Administration (anastrozole, letrozole, and exemestane) are highly selective competitive inhibitors/inactivators of the aromatase enzyme.
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The project was approved by the Australian Institute of Sport (AIS) and the Instituto Boliviano de Biología de Altura ethics committees.
The FDA has not approved either of these two AIs for breast cancer risk reduction, and their use in the US is considered off-label.
AR, androgen receptor; AIS, androgen insensitivity syndrome; CAIS, complete androgen insensitivity syndrome; PAIS, partial androgen insensitivity syndrome All authors read and approved the final manuscript.
The study cohort for this IRB (institutional review board) approved prospective cohort follow-up study consisted of prospectively enrolled consecutive adult patients presenting to our academic ED with AIS.
(They approved).
(She approved).
Calvin approved.
Jeanette approved.
He approved.
All approved.
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