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Abnormalities in the CFTR leads to decreased chloride secretion and increased sodium absorption in these cells, resulting in dehydration of the airways surface layer and subsequent viscous tenacious mucus.
The content of the secretory vesicles water, ions, and other molecules present in the luminal surface of the epithelium will form the mucus layer, characteristic of the airways surface [ 13].
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alpha-1-antitrypsin. airway surface liquid.
Figure 1 Optical scanning to measure airway surface liquid volume.
In the lungs, abnormal function of chloride channels results in a dehydrated airway surface.
The airway surface liquid is cleared from the lung by ciliary transport, surface tension gradients, and airflow shear forces.
Exposure to dry air also increases the osmolarity of airway surface fluid.
Immunity was associated with protection against challenge with recombinant vaccinia gag at an airway surface.
This provides an indication that DTPA absorption will provide a robust measure of airway surface liquid modulation in vivo.
This airway surface liquid is a bilayer composed of a viscoelastic mucus layer supported by a fluid film known as the periciliary liquid.
Because of the irregular motion of 4DCT-based airways, we identified an optimal interpolation method for airway surface deformation during respiration, and implemented a computational solid mechanics-based moving mesh algorithm to produce smooth deforming airway mesh.
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