To gain new insights into the mode of action of AZT in airways, we evaluated its effect on gene expression in well-differentiated primary human bronchial epithelial (HBE) cultures using RNA expression microarrays and measurements of secreted IL-8.
33 children aged between 4 and 38 months, without structural anomalies of the conductive airways were evaluated.
The following airways were evaluated: membranous bronchioles and first-generation respiratory bronchioles cut in cross-sectional and perpendicular planes to the longitudinal profile of the airway, respectively.
Segments of reconstructed airway were evaluated grossly and histologically for all animals.
Herein, the tissue-engineered airway strategies, evaluated in preclinical studies and translated (or are to be) to clinical practice, will be reported.
The next day, her airway was evaluated by an otolaryngologist.
After placement of a size 2.5 laryngeal mask, anesthesia was maintained with 2.5% sevoflurane, and the airway was evaluated by a fiberscope 2 h later under spontaneous breathing through the laryngeal mask before the end of anesthesia.
The maximum mean airway pressure evaluated was 30 cmH2O.
Endogenous airway acidification evaluated as pH in exhaled breath condensate (EBC) has been described in patients with chronic cough.
The percentage of eosinophils in the lung parenchyma and the airway was evaluated through morphometric analysis using a reticule of known area (50 lines and 100 dots) and a microscope (CH30, Olympus, Japan).
In this study, authors concluded that airway inflammation evaluated either by changes in exhaled nitric oxide or sputum cells counts was not improved after a dual NK1/NK2 antagonist [ 13].
