Sentence examples for airway defect from inspiring English sources

We found increasing evidence of chronic airway obstruction (FEV1/FVC%, PEF, MEF25, MEF50, MEF75, and small airway hyperreactivity) and restriction (FVC, restrictive airway defect) with increasing quintiles of soil Cs in the NCC children.

Importantly, all engineered tissues had similar or improved biomechanical properties compared to rat tracheas, which suggests they could be transplanted into a small animal model for airway defects.

For instance, Foxj1 knockout mice have left-right asymmetry and airway defects (Brody et al., 2000).

Airway clearance may be impaired in disorders associated with abnormal cough mechanics, altered mucus rheology, altered mucociliary clearance, or structural airway defects.

In the mouse, a species with a general paucity of submucosal glands, expression of human CFTR in ciliated cells of CFTR−/− mice is capable of correcting the airway defects in Cl− secretion and Na+ absorption (Ostrowski et al. 2007).

To our knowledge, this is the first demonstration of three-dimensional modeling of an upper-airway defect with subsequent T-tube design using engineering software.

Interestingly, in developing airways defects in Clara cells differentiation were similar between Pofut1/Shh-Cre and Rbpj/Shh-Cre mutants [37]; however, defects in neuroendocrine cells differentiation were more severe in Pofut1 deletion than in Rbpj deletion and it was ascribed to a marginal reduction of Hes1 expression by Rbpj deletion [38].

Better understanding of ΔF-CFTR biology, physiology and lung and airways defects is critical, because the majority of the associated pathology and corresponding mortality of CF occurs in the pulmonary system.

While this concept is supported by the presence of pathogens in lungs of patients exhibiting defects in mucus clearance [ 6– 8], the roles of the primary defects (airway surface liquid dehydration, dehydrated/concentrated mucus, lack of ciliary beat, decreased mucus clearance) in establishment of chronic inflammation are not fully appreciated.

In the airways, the genetic defect impairs mucociliary clearance as well as antimicrobial defense creating a perfect niche for microbial colonization.

We discovered that human and mouse CF airways exhibit a defect in autophagy, as indicated by reduced autophagosome formation, and the accumulation of sequestrosome 1 (SQSTM1) [22], a major autophagic substrate also known as p62 [31].