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We recently designed a PEG-coated cationic liposome targeted to angiogenic vessels and showed, in a murine dorsal air sac model, potent anti-angiogenic activity of an oxaliplatin (l-OHP) formulation of this liposome.
To confirm our in vitro findings, we also examined whether puPA, puPAR and pU2 could inhibit tumor angiogenesis in vivo using the dorsal air sac model.
Furthermore, addition of purified SpeB with either a wild-type or ΔspeB M1 strain into a mouse air sac model of infection led to accelerated and increased tissue necrosis, as well as dissemination of the organism away from the initial site of infection [47].
The mtsABC mutant strain was ∼30-fold less virulent compared to wild-type in an in vivo mouse air sac model of subcutaneous infection.
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This study was designed to investigate histopathologically the therapeutic efficacy of lead peptide RIP YSPWTNF-NH2 in the subcutaneous air sac murine model of acquired S. aureus sepsis.
Compared to the parental A-20 strain, the perR mutant was attenuated for virulence in a BALB/c mouse skin air sac infection model of GAS infection, consistent with previous reports (Ricci, Janulczyk and Bjorck 2002; Brenot, King and Caparon 2005; Gryllos et al., 2008).
Chimps have a vocal air sac, for example, but humans don't.
It is therefore encouraging that the predicted body mass of our volumetric reconstruction (72.172 kg) essentially matches that measured by Smith et al. [58] for their specimen, although some caution is warranted as were unable to quantitatively validate estimated air sac volumes in our model.
Addition of an abdominal air sac to our best estimate models (Supporting Information Tables S1: 1–49) had a modest affect on mass predictions, reducing total body by between 1.3 2.98% in the non-avian theropods.
Changing air sac volumes in the largest and smallest models to exaggerate mass effects had less than +/−2% effect on total body mass in these models.
Phase I of our model of the evolution of air sacs highlights the variable expression of the cervical air sac system in posterior portions of the axial column in theropods (Figure 17).
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