Since 9i retained very weak, but distinct, PPARγ agonist activity, we next modified the distal benzene ring of 9i, aiming to delete the residual PPARγ agonist activity while retaining the antagonist activity.
Where gaps in the known genome sequence imposed alternative strategies, we aimed to delete or disrupt at least the protein kinase domain (see Figure S2A for all construct designs).
The development of high-throughput phenotyping has further increased the available amount of phenotype data resulting from targeted mutations in animal models, and pan-genomic projects such as the International Mouse Phenotyping Consortium (IMPC) (Brown and Moore, 2012) aim to delete every protein-coding gene in an organism and to identify the phenotypes resulting from these mutations.
By crossing these fRIM1 mice to previously characterized transgenic cre lines, we aimed to delete RIM1 selectively in the dentate gyrus (DG), using a specific preproopiomelanocortin promoter driving cre recombinase (POMC-cre) line, and in pyramidal neurons of the CA3 region of hippocampus, using the kainate receptor subunit 1 promoter driving cre recombinase (KA-cre).
The aim of SMFA is to delete, remove, or destroy the digital watermark by modifying the signal of the audio file.
The aim in the first stage of our algorithm is to delete those "impossible" regulatory associations that are truly-false.
An instruction to delete emails, which were not deleted.
"Seriously you have to delete it".
She urged people to delete Snapchat.
Q: Will Facebook have to delete data?
