Where gaps in the known genome sequence imposed alternative strategies, we aimed to delete or disrupt at least the protein kinase domain (see Figure S2A for all construct designs).
The development of high-throughput phenotyping has further increased the available amount of phenotype data resulting from targeted mutations in animal models, and pan-genomic projects such as the International Mouse Phenotyping Consortium (IMPC) (Brown and Moore, 2012) aim to delete every protein-coding gene in an organism and to identify the phenotypes resulting from these mutations.
By crossing these fRIM1 mice to previously characterized transgenic cre lines, we aimed to delete RIM1 selectively in the dentate gyrus (DG), using a specific preproopiomelanocortin promoter driving cre recombinase (POMC-cre) line, and in pyramidal neurons of the CA3 region of hippocampus, using the kainate receptor subunit 1 promoter driving cre recombinase (KA-cre).
He added that, while planning to move offices, News International had decided on a new policy for deleting emails, aiming to clear the archive.
Aiming to address the privacy concerns of disenchanted users, Facebook.com said on Tuesday that it was trying to make it easier for people to delete their accounts permanently from the social networking site.
The Metropolitan police is aiming to be able to submit a note to the Leveson inquiry next month providing more detail on how murdered teenager Milly Dowler's voicemail messages came to be deleted after she went missing in 2002.
The IC aims to recover the data deleted in the transmitter so as to eliminate the ICI, in other word, compensate the loss caused by ICI.
The aim of SMFA is to delete, remove, or destroy the digital watermark by modifying the signal of the audio file.
However, under the hood, the new software also includes a fix which aims to address the troubling issue of iTunes deleting some users' music files from their computer.
Mailbox – an iPhone and iPad app which aims to help people de-clutter their Gmail inboxes by swiping to archive, delete or "snooze" emails until later – wasn't just an overnight success, either.
