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The aim of target discovery is the identification and validation of suitable drug targets for therapeutic intervention, whereas lead discovery identifies novel chemical molecules that act on those targets.
Detemir was initiated as once daily and titrated according to manufacturer labeling and a published "treat-to-target" titration algorithm described by Holman et al. (15, 16), with an aim of target fasting plasma glucose (FPG) concentrations of <5.5 mmol/L (<99 mg/dL) before breakfast and before dinner.
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The commission's aim of targeting inequalities in York met a virtually universal welcome in theory.
The ban theoretically extends to foreign news sources, with the apparent aim of targeting French-language Belgian and Swiss media that broke previous embargoes.
But we soon realised that we couldn't make a significant difference to the problem on our own, so we set up a consortium of seven colleges (Harris, Manchester, Hertford, Keble, New College, St Hugh's and Worcester in addition to ourselves) with the common aim of targeting the sector to encourage more applications from it.
Firefox OS was first unveiled in 2013, with the aim of targeting the developing world and late adopters with low-cost handsets.
The main aim of targeted application of complement inhibitors is to reduce any potential side effects whilst trying to treat a condition [66].
Traditionally drugs have been designed with the aim of targeting a single biological entity, usually a protein (the so-called "on-target"), with high selectivity to avoid any unwanted effects arising from mis-targeting other biological targets ("off-targets").
Inhibitors of the Grb2 and Src SH2 domains have been extensively studied, with the aim of targeting the Ras pathway and osteoclastic bone resorption, respectively.
Thus, it is particularly important that systems do not function within a single vertical silo or product ecosystem, whether through technical constraints (e.g. only operating with other products by the same producers) or functionality (e.g. only operating with other systems with the aim of targeting a particular goal).
Much of that had been lost on this most dispiriting of trips, when Australia's stated aim of targeting him with both bat and ball paid dividends in a way that even the wild fantasies of coach Darren Lehmann and captain Michael Clarke could not have envisaged.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com