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Inhibitors of SH2 and SH3 domains were designed with the aim of interrupting Grb2 recognition.
In 1646, after several naval successes against Spain along the Mediterranean, Cardinal Mazarin planned a naval expedition to attack the Spanish puppet State of Presidi with the aim of interrupting Spanish communications with the Kingdom of Naples, threatening the initial stage of the Spanish Road, and also to scare the pope Innocent X, whose Spanish sympathies displeased him.
PENT is not dependent upon patients' collaboration and could be performed at an early stage to detect initial functional derangement and to use the results to start investigational treatments with the aim of interrupting pathological mechanisms at their onset.
Based on the assumed inhibition by antithrombin of activated clotting factors in the circulating vascular system, concentrated human plasmatic antithrombin was administered in the setting of DIC in isolated cases [ 2, 4- 6, 8], in animal experiments [ 6, 9- 13], and in clinical studies [ 14- 18] with the aim of interrupting the complex cycle of DIC and preventing multiple organ failure.
However, in the presence of substantial within-host variability, our results indicate that rather than seek out supershedders themselves, the most effective controls would directly target the phenomenon of pathogen supershedding with the aim of interrupting or preventing high shedding densities.
Similar(54)
To this aim, the probability of interrupting CPR as a function of time has been proposed as a new evaluation figure.
Here we investigate the consequences of interrupting the elongation process.
Examining the consequences of interrupting mitochondrial fusion raises further considerations.
Be mindful of interrupting another person.
This will reduce the risk of interrupting a conversation or needlessly interrupting their meal.
We assume the attackers might report false events with the aim to interrupt the functionalities by trustable nodes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com