The 95% limits of agreement according to the method of Bland and Altman are presented in Figures 2, 3, 4, 5.
The association between the difference SUVPET1 and SUVPET2 will be examined by calculating Spearman's rank correlation coefficient and by analyzing the agreement according to the method proposed by Bland and Altman [ 21].
Those reporting that their beliefs were unchanged will be included in a test-retest analysis by calculating an intra-class correlation co-efficient (ICC) [ 41], and by calculating limits of agreement according to the method of Bland and Altman [ 42].
All tests in this study were therefore evaluated in terms of statistical agreement according to the methods outlined in the FDA guidance document on appropriate statistical methods used for evaluating diagnostic tests [ 12].
Inter- and intra-observer reproducibility of ADC and SUV of tumours were determined as mean absolute difference (bias) and as 95%% confidence interval (CI) of the mean difference (limits of agreement), according to the methods of Bland and Altman [ 19].
One of the main problems is the lack of agreement on the method to acquire and analyse the data so it is difficult to compare the results from one site with another.
Also, within a regulatory decision process like the SVHC identification in REACH, it would be necessary to seek agreement on the method of assessment as well as the conclusions of it.
For each probe on the Affymetrix array, we derived a present/absent call by scoring 'present' if a signal was detected in ten or more of the 20 samples analyzed, in agreement with the method used to collapse replicates by DNA Chip Analyzer [29].
For each probe on the Affymetrix array, we derived a present/absent call by scoring 'present' if a signal was detected in ten or more of the twenty cell samples analyzed, in agreement with the method used to collapse replicates by DNA Chip Analyzer [29].
The most abundant class was rRNA, in agreement with the method used to obtain sRNA fraction for library preparation.
Bias and limits of agreement were calculated according to the method of Bland and Altman [ 19].
