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In the AGREE study, many patients attained low disease activity, an alternative therapeutic target to remission.
The population analyzed here represents a subset of the original AGREE study, including only patients with complete datasets.
Of the 87 sites that had enrolled patients in the initial 2-year, randomised AGREE study, 35 sites enrolled patients in the AGREE substudy.
DAS28 (ESR) was used for enrolment criteria, whereas DAS28 (C reactive protein, CRP) was used for all disease activity assessments, including baseline measurements (to reflect the AGREE study).
In the AGREE study, MTX-naïve patients with early RA who had been treated with abatacept plus MTX experienced clinical, functional and structural benefits, and improvements in disease activity, versus patients treated with MTX alone [ 15].
In the original AGREE study, 253 and 256 patients were randomized to receive MTX alone and abatacept plus MTX, respectively; 227 and 232 patients, respectively, completed the 12-month, double-blind period [ 15].
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Authorship and publication will be as per the agreed study publication policy.
But technology offered opportunities too, it was agreed; studying online can give students the confidence to enrol on a higher degree course.
Reich agrees: "Studying those interactions should provide a lot of information".
The results of the present study agree with studies performed in other species.
They agree more study is needed.
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