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A similar mitochondrial theory of aging proposes a mechanism in which electrons leaking from the electron transport chain (ETC), the central component of the organelle's respiration machinery, produce ROS and then damage ETC proteins and mitochondrial DNA, leading to further increases in intracellular ROS levels and a decline in mitochondrial function.
The molecular inflammation hypothesis of aging proposes that redox dysregulation causes an age-related activation of NF-κB and its signaling to upregulate various proinflammatory genes.
The dedifferentiation theory of aging proposes that a reduction in the specificity of neural representations causes declines in complex cognition as people get older, and may reflect a reduction in dopaminergic signaling.
The gene regulation theory of aging proposes that senescence is the resulting of changes occurring in the gene expression (Kanungo 1975; Weinert and Timiras 2003).
The free radical theory of aging proposes that ROS (reactive oxygen species) are major driving forces of aging, and are also critically involved in cellular senescence.
The mitochondrial "vicious cycle" theory of aging proposes that accumulation of mtDNA mutations may lead to enhanced mitochondrial ROS production and subsequent increased oxidative stress during aging [ 35].
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Originally the free radical theory of aging proposed that, during the aging process, damaged mitochondria produced increasing amounts of ROS leading to tissue damage [ 35].
This proposal is in line with the "heterochromatin island" hypothesis of aging proposed earlier.
Members of the House Ways and Means Health Subcommittee and the Senate Special Committee on Aging proposed measures to require nursing homes to disclose ownership and to require regulators to release information about poorly managed homes.
On Tuesday, the issue was on the agenda of the city council in Berkeley, with the city's Commission on Aging proposing that the city explore the possibility of municipal ownership of electricity generation and transmission as a response to what it called punitive rate increases by the Pacific Gas and Electric Company.
These empirical observations should be contrasted with certain implications of the free radical theory of aging proposed by Harman (1956).
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