Sentence examples for aging pathways in from inspiring English sources

Of note, most of the studies summarized here provide mainly descriptive evidence for an involvement of specific aging pathways in BPD.

In particular, this model organism develops an array of senescence symptoms resembling those in humans [61] [62] [63] [44], and is amenable to large-scale genetic screens that can be targeted to conserved aging pathways in vertebrates [42].

A principle component analysis of these shared GO terms using REViGO term clustering and analysis further indicated the presence of shared canonical aging pathways in the 5 age-related disease categories (Fig. S2, Supporting information).

There has, however, been little direct evidence that this is true in normal human aging and age-related disease, and the role of canonical aging pathways in human age-related pathologies has not been established.

Because of this consistent association between higher plasma IL-6 and adverse health outcomes, IL-6 was named "the gerontologist's cytokine" by William Ershler, who speculated that this cytokine regulates a key aging pathway in man[39].

Zebrafish show an array of senescence symptoms resembling those in humans, which can be targeted to specific aging pathways conserved in vertebrates.

This novel aging model, which allows efficient large-scale isolation of old cells, may facilitate biochemical characterizations and genomics/proteomics studies of cellular aging, and help to verify the aging pathways observed in other organisms including S. cerevisiae.

We propose that early alterations in major aging pathways drive premature aging of the lung thereby adding to the risk for development of chronic lung diseases later in life [9, 10].

Until now, acetylation had not been directly implicated in the aging pathway, so this is a new role and potential target for prevention or treatment strategies, the researchers said.

We instead provide strong evidence that, at physiological levels, acetic acid promotes aging simply by activating pro-aging pathways in yeast, analogously to glucose and ethanol.

Thus main pro-aging pathways in Drosophila include insulin/FOXO/TOR, TOR, JNK, NF-kB [ 46, 47, 145, 147, 157- 162].