Aging is the deterioration of desirable properties during storage or service; this is a phenomenon common to a wide variety of natural and synthetic rubber, including NR [40].
The consequence of aging is the deterioration of tissue function mainly due to accumulation of damaged DNA, proteins, and organelles.
This view declared that aging is just deterioration and functional decline due to an accumulation of random molecular damage from myriad causes, and refractory to substantive intervention [ 6, 7].
Skin aging is characterized by deterioration of the dermal collagen fiber network due to both decreased collagen expression and increased collagenolytic activity.
It has been shown that aging is associated with deterioration of brain functioning (e.g., [ 12, 13]).
Aging is associated with deterioration of physical and mental functions as well as increased morbidity and mortality.
We may speculate that aging is associated to deterioration of rheological blood behavior which could explain the dilated capillaries not found by Russell and co-workers.
Aging is a progressive deterioration of physiological functions impairing the ability of an organism to cope with endogenous or exogenous stresses and maintain homeostasis.
It is believed that aging is a decline, deterioration due to accumulation of random molecular and cellular damage caused by free radicals, radiation, stresses, pathogens, toxins, carcinogens, mistakes in replication/translation, protein misfolding and even mechanical forces.
Aging is associated with deterioration of both innate and adaptive immune responses, which contributes to increased susceptibility to infections, decreased vaccine responses and impaired wound healing in the elderly (Linton & Dorshkind, 2004; Gomez et al., 2008; McElhaney & Effros, 2009; Mahbub et al., 2011; Montecino-Rodriguez et al., 2013).
The normal process of aging is associated with progressive deterioration in both structure and function of various molecular, cellular, and tissue components that can be influenced by both genetic and environmental factors.
