Exact(4)
And life span extension by mild damage makes no sense, if aging is a decline caused by accumulation of damage.
While rejecting ROS-driven aging, scientists still do not dare to reject the view that aging is a decline due to accumulation of random damage.
Since one characteristic of aging is a decline in the regenerative potential of mesenchymal tissues, these results supports the hypothesis that the homeostasis of hMSCs from individuals suffering premature aging diseases is hampered.
It is believed that aging is a decline, deterioration due to accumulation of random molecular and cellular damage caused by free radicals, radiation, stresses, pathogens, toxins, carcinogens, mistakes in replication/translation, protein misfolding and even mechanical forces.
Similar(56)
Among the hallmarks of aging are a decline in learning, cognition and memory.
Cognitive decline in aging is a pressing issue associated with significant healthcare costs and deterioration in quality of life.
GFR decline with aging is a well-known phenomenon, and reference values should take it into account [ 7, 8].
Accompanying the natural advancing of age is a decline in cognitive and motor functions, which can significantly impact the daily life activities in the elder demographic (>65 y).
Accompanying the natural advancing of age is a decline in cognitive and motor functions, which may be the result of altered neuroplasticity, due to changes in synaptic function and neurotransmission.
In adapting the SRM, we did not however assume that aging was a process of decline.
Before Guarente entered the field of longevity, the conventional wisdom held that aging was a series of haphazard declines, a result of renegade genes ungoverned by natural selection.
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