While the presence of abundant lipofuscin in endothelial cells)—usually associated with aging and indicative of a highly oxidized and covalently cross-linked aggregate of proteins is evidence of a dysfunctional lysosomal degradation not expected in children or young adults.
Although there were no gross phenotypic abnormalities at birth, subtle epidermal anomalies were present that disappeared by one month of age, indicative of a robust injury response.
They found that BLLs at 2 4 years of age (mean, 4.58 μg/dL) were associated with excessive responding on the DRL task at 9.5 years of age, indicative of impaired response inhibition.
This cohort effect, however, was not observed in other clusters, such as the low PAT exposure clusters (Fig. 3D), where the age-specific HCV prevalence increased steadily with age, indicative of a steady exposure to HCV infection.
Tongue pressure (pressure exerted by the the tongue on the hard palate) is significantly decreased with age indicative of muscle fatigue, specifically of the infrahyoid and suprahyoid muscles, which may affect swallowing as well as increase the risk of aspiration.
A maximum of seven nodal calibration points were used (six for the genetic tree; see Additional file 13 for list of calibration points and age-indicative fossils), along with tip calibration dates (see Additional file 14) for the unconstrained and constrained analyses.
Collectively these results support the conclusion that the miRNAs identified may play an important role in staving off cellular senescence and their altered expression could be indicative of aging.
The spikes shown in each respective census for childbearing women currently aged 15 49 are indicative of age heaping.
The decline in antibody from 6 months of age and seroconversion at approximately 13 months of age is indicative of loss of maternal immunity followed by active seroconversion.
There is evidence that decreased telomere length, indicative of tissue aging, is potentiated in adipose tissue by obesity (17).
