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Abnormal increase in NO release has been reported to be involved in premature skin aging, in part via its stimulatory effects on reactive oxygen species and apoptotic pathways [25] [28].
This suggests that TORC1 promotes aging in part via inhibition of autophagy.
Cellular aging (in part by causing age-related diseases) leads to non-random tissue, organ and system damage, ultimately causing organismal death.
Previous work suggests that insulin signaling may modulate Drosophila aging in part through its impact on juvenile hormone titer, but no data yet address whether reduction of juvenile hormone is sufficient to control Drosophila life span.
The major factor controlling the longevity benefits of protein restriction in multiple species is the ratio of dietary protein to other macronutrient calorie sources (carbohydrates, fats), which is likely to affect aging in part through the regulation of mTORC1 signaling (Solon-Biet et al., 2014).
We propose that subjective recollection impairments may be observed in older adults in conjunction with altered neural activity with an MTL parietal network, as with the low-functioning participants here, whereas objective recollection impairments may be more pervasive in aging, in part, due to altered executive control processes within the PFC, consistent with the frontal-aging hypothesis.
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The project 'Good Aging in Skåne', part of the Swedish National Study on Aging and Care, was supported by the Swedish Ministry of Health and Social Affairs and the Vårdal Institute.
Number of senescent cells increase with aging in different parts of the body and also contribute in cardiac disease [ 40, 41].
The overall increase in childbearing age may in part be due to parents putting off having children until they are more financially secure, suggested Siobhan Freegard, founder of Channel Mum, a video-based social network site.
It has been hypothesized that individual differences in cognitive ageing might in part be based on the relative preservation of speed of information processing.
Therefore, adjustment for age may in part reflect overadjustment for exposure.
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