Exact(7)
Overall, we conclude that aging exacerbates the functional defect of L2AKO mice and reduces hepatocyte viability.
Recent studies demonstrate that aging exacerbates hypertension-induced cognitive decline, but the specific age-related mechanisms remain elusive.
To determine whether aging exacerbates hypertension-induced CMHs young (3 months) and aged (24 months) mice were treated with angiotensin II plus L-NAME.
In conclusion, the results of this study show that aging exacerbates hypertension-induced CMHs in a mouse model that recapitulates cerebromicrovascular alterations present in elderly humans.
While the deleterious effects of hypertension of large vessel atherosclerosis and development of debilitating strokes are well documented (Rajan et al., 2014), the microvascular mechanisms by which aging exacerbates hypertension-induced neuronal dysfunction are less understood.
When viewed within the broader context of prior studies, the findings presented herein suggest that aging exacerbates hypertension-induced production of ROS and activation of MMPs in the wall of cerebral vessels, which likely renders them more vulnerable to high pressure-induced rupture.
Similar(53)
We found that the regularity index was similar in normotensive young and aged mice, whereas aging exacerbated hypertension-induced decline in gait function (Fig. 2).
With trends like urbanization and aging exacerbating rates of HIV/AIDS and chronic diseases like diabetes, the London-based Wellcome Trust will merge its chronic and infectious disease research into the Health Consequences of Population Change program.
Here, we examine whether adrenomedullin deficiency and aging exacerbate ischemic white matter injury after prolonged cerebral hypoperfusion.
The study reveals that gender discrimination reduces the size of the population and the number of laborers, accelerates the speed of aging, and exacerbates the marriage squeeze.
A further challenge stems from the fact that facial aging often exacerbates the effects of acne scarring.
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