Sentence examples for aging exacerbate from inspiring English sources

Here, we examine whether adrenomedullin deficiency and aging exacerbate ischemic white matter injury after prolonged cerebral hypoperfusion.

We found that the regularity index was similar in normotensive young and aged mice, whereas aging exacerbated hypertension-induced decline in gait function (Fig. 2).

With trends like urbanization and aging exacerbating rates of HIV/AIDS and chronic diseases like diabetes, the London-based Wellcome Trust will merge its chronic and infectious disease research into the Health Consequences of Population Change program.

Overall, we conclude that aging exacerbates the functional defect of L2AKO mice and reduces hepatocyte viability.

Recent studies demonstrate that aging exacerbates hypertension-induced cognitive decline, but the specific age-related mechanisms remain elusive.

To determine whether aging exacerbates hypertension-induced CMHs young (3 months) and aged (24 months) mice were treated with angiotensin II plus L-NAME.

In conclusion, the results of this study show that aging exacerbates hypertension-induced CMHs in a mouse model that recapitulates cerebromicrovascular alterations present in elderly humans.

While the deleterious effects of hypertension of large vessel atherosclerosis and development of debilitating strokes are well documented (Rajan et al., 2014), the microvascular mechanisms by which aging exacerbates hypertension-induced neuronal dysfunction are less understood.

In contrast, MMP activity was substantially increased in high pressure-exposed arteries of aged mice as compared to vessels of the same animals exposed to 60 mmHg (Fig. 4A, B) indicating that aging exacerbates high pressure-induced MMP activation in cerebral vessels (Fig. 4B).

When viewed within the broader context of prior studies, the findings presented herein suggest that aging exacerbates hypertension-induced production of ROS and activation of MMPs in the wall of cerebral vessels, which likely renders them more vulnerable to high pressure-induced rupture.

Vascular Nrf2 dysfunction associated with aging would exacerbate cellular oxidative stress and increase the sensitivity of aged vessels to cellular damage.