The phrase "aging disorder" is correct and usable in written English.
It can be used to refer to medical or psychological conditions that are associated with the aging process.
Example: "Researchers are studying the effects of aging disorder on cognitive function in elderly patients."
Alternatives: "age-related condition" or "geriatric disorder".
Hutchison-Gilford Progeria Syndrome (HGPS) is a rare, accelerated aging disorder caused by nuclear accumulation of progerin, an altered form of the Lamin A gene.
Alzheimer's disease (AD) is an aging disorder that leads to memory loss.
We suggest that PABPN1 levels regulate muscle cell aging and OPMD represents an accelerated muscle aging disorder.
AD is an aging disorder characterized by deposition of extracellular β-amyloid (Aβ) plaques and intraneuronal tangles containing hyper-phosphorylated Tau (p-Tau) (Hardy & Selkoe, 2002).
Werner Syndrome (WS) is an autosomal recessive segmental aging disorder associated with a marked predisposition to cancer and vascular disease [ 1, 2].
Hutchinson Gilford progeria syndrome (HGPS, OMIM 176670) is a rare segmental premature aging disorder associated with rapid growth deceleration in childhood (Gordon et al., 2014).
In this scenario, premature aging disorders in humans and the various animal model systems recapitulating the phenotypes of accelerated aging and cellular senescence constitute a major area of interest in understanding the intricacies of the process of aging.
SIRT1, being the most extensively experimented sirtuin with regards to aging and longevity, has triggered interest in scientific communities to develop small molecule activators or drugs in amelioration of a wide range of aging disorders.
Taken together, our study compares and contrasts the distinct pathologies underpinning the two premature aging disorders, and provides reliable stem-cell based models to identify new therapeutic strategies for pathological and physiological aging.
A potentially successful approach involves the analysis of naturally occurring aging disorders [ 1, 2].
According to our hypothesis premature aging disorders as well as normal aging should share features with mitochondrial disease.
