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Aging constitutes the central risk factor for major diseases including many forms of cancer, neurodegeneration, and cardiovascular diseases.
Aging constitutes a major independent risk factor for the development of type 2 diabetes and is accompanied by insulin resistance and adipose tissue dysfunction.
Aging constitutes a significant risk factor for fibrosis, and idiopathic pulmonary fibrosis (IPF) is characteristically associated with advancing age.
While interstitial lung disease can affect both the young and the elderly, aging constitutes a significant risk factor for pulmonary fibrosis.
Perhaps not coincidentally, aging constitutes one of the major factors reducing the proliferation of NSCs [ 19- 21] while cognitive decline, including a reduced learning and memory performance, is commonly observed in aged individuals [ 22- 24].
Therefore, chronological aging constitutes a model for differentiated somatic cells.
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We posit that increased adipokine and decreased IL-15 levels during aging constitute a common mechanism for sarcopenia, obesity, and immune senescence.
Clinical key hallmarks of ROS-induced skin aging constitute wrinkle formation, decreased resilience, skin laxity, pigmentation changes, telangiectasia, overall dehydration of the skin.
The negative effects of globalization, rapid urbanization, sedentary lifestyles, and poor dietary habits, together with trends of population aging, constitute considerable challenges for governments and public health stakeholders [ 1].
Worldwide, the aged constitute an increasingly large and challenging segment of the human population.
Our results showing that a diet matching a "Western-type" dietary pattern in middle age may be a risk factor for not achieving ideal healthy aging constitute a novel finding.
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