Exact(10)
For example, aging altered macrophage polarization in splenic macrophages but not in BMDMs (Mahbub et al., 2012).
In cerebellum, for example, at a type I error rate of 0.001, aging altered the expression of 2168 of 21327 genes (10.2%).
The customary P (without subscript) represents a two-sided p-value, generated by testing whether CR or aging altered gene expression in either direction (up or down).
On average, aging altered 22.9% of genes, with the strongest effects found in the cortex (44.0% of genes differentially expressed) (P < 0.05).
This percentage is considerably higher than that observed in the AGEMAP project [ 29], in which aging altered the expression of only 17 of 8932 genes (0.19%) (P < 0.001).
Because Ca2+ imbalance plays an important role in hippocampal CA1 loss of function with aging, altered hippocampal CaM-KK activity with age may also play a role in selectively altering nuclear pAKT308 phosphorylation across lifespan in area CA1.
Similar(50)
How does reproductive aging alter vulnerability to AD in females?
How does reproductive aging alter vulnerability to AD in males?
Castle et al have demonstrated that physiologic changes of the cervix that occur with aging alter the HPV subtypes found in older women.
Considering these evidences, aging alters the function of adipose cells, and alteration in secretion of adipocytokines attenuates insulin sensitivity.
Aging alters the function and number of adipose cells which cause alterations in the secretion and function of the adipocytokines such as leptin and adiponectin [ 101].
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