Critical questions for the future include determining the causes and mechanisms for the observed down-regulation of mitochondrial and ETC genes during aging - a pattern shared by Drosophila and mammalian tissues [ 6, 9].
Interestingly, the anti-gSG6 IgG response decreased with age, a pattern that is in contrast with the typical development of the humoral response to parasite antigens.
Declining prevalence with age, a pattern suggested by period data, is not observed among real birth cohorts as they age.
There has been plenty of time since the origin of multicellular animal for lineage selection to operate, and cancer is a relatively rare disease, except in individuals of postreproductive age, a pattern consistent with successful selection.
In our study the adjuvanted split virion vaccine was highly immunogenic, even in young children, but was slightly less immunogenic in older children than in infants (3% per year with age), a pattern not previously described for inactivated vaccines.
Similarly, the percentage of respondents who self-rated their health status as fair or poor was higher among women and increased with age, a pattern also found in the reports of limitation of physical activities and presence of chronic disease.
In our study, infection rates were higher for persons >40 years of age, a pattern believed to be caused by longer exposure and accumulation of parasites (4, 9, 11 ).
Country and baseline age explained variation in effects: studies with older baseline age showed a pattern of protective effects (HR < 1.00) for openness, and U.S. studies showed a pattern of protective effects for extraversion.
In more recent years, there is a linear increase in male rates in Sri Lanka and China with age - a pattern typical of that seen in many western countries [ 2, 18].
Similarly, a study on Nicotiana exhibited stability of correlation patterns of length characters rather than width characters of flowers independent of cyme position, flower position and flower age, showing a pattern of shared developmental regulation [ 31].
Further evidence that supports this theory includes a meta-analysis [ 41] demonstrating that the human cortex has a reproducible genomic aging pattern whilst the cerebellum does not.
