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Intracellular accumulation of lipofuscin is a feature of postmitotic aging (40).
Clusterin may have a role in protecting organisms from apoptosis because of oxidative stress (39) and may prevent glomerulopathy associated with aging (40).
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But deficient clearance of senescent cells will induce inflammation, impair adjacent cells and tissue function, and lead to stem cell exhaustion, and finally contribute to aging [40].
Can you imagine if Tom Brady were an aging 40-year-old backup for the Buffalo Bills, but the media still covered him like he was the four-time Super Bowl winner for the New England Patriots?
Therefore in these cases one could hypothesize that the exposure of cells to non-lethal oxidative stresses for a considerable period of time may be associated with aging [40].
aged 97.
He was aged 42.
She died aged 59.
September 4, aged 61.
2006 Pinochet dies, aged 91.
He died aged 30.
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