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Information about protein-protein interactions (PPI) were from APID (Agile Protein Interaction DataAnalyzer) which integrates and unifies PPI from different public repositories [ 34].
In silico approach to assess the network of the genes in a PPI of PARK2, using Agile Protein Interaction Database (APID), a comprehensive resource for protein interaction data, automatically accessed by cytoscape 22 through the dedicated plugin APID2NET, 23 was carried out to understand the involvement of the studied interactome.
Protein-protein interaction (PPI) data have been retrieved from the Agile Protein Interactions Database APID [ 80] accessed through the dedicated plugin APID2NET [ 81] and from the metadatabase InnateDB [ 82] and then integrated to form the Tcf7l2 interactome (i.e. the set of molecular interactions related to Tcf7l2) and analyzed with the network analysis platform Cytoscape [ 83, 84].
Others, such as Interaction Reference Index (iRefIndex) (13), Agile Protein Interaction DataAnalyzer (APID) (14) and Michigan Molecular Interactions (MiMI) (15) aim to redistribute and make available a non-redundant set of protein interactions for all species for convenient access over the web or via software tools, like Cytoscape (16).
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