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Conversely, the expression signatures of primary tumors generated by more aggressive variants, and their matched metastases in the lungs and lymph nodes, all tended to converge.
An important aspect of our findings is that hypoxia-mediated chromaffin metaplasia appears to occur across the clinical spectrum of sympathetic neuroblastic tumors, ranging from ganglioneuroma through to highly aggressive variants of the disease - and that this is also observed in cell lines.
IHC and FISH were performed in a cohort of 259 thyroid carcinomas enriched for aggressive variants.
The appearance of nullipotent EC cells may reflect selection of more aggressive variants during cancer progression.
Recommendations from a multidisciplinary committee on aggressive variants of CRPC have been published recently [ 88].
It has been linked to motility and is highly expressed in aggressive glioma cell lines versus less aggressive variants [ 46].
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Given what is now known about cancer of the cervix, the possibility exists that Peron infected both wives with a particularly aggressive variant of human papilloma virus, causing the cancer in both, or that his first wife infected him and he passed the infection along to Eva.
Plasmablastic lymphoma (PBL) is a rare aggressive variant of diffuse large B-cell lymphoma.
Papillary meningioma (MP) is a rare and aggressive variant of meningioma, occurring preferentially in young subjects.
Ductal adenocarcinoma (DCa) is an aggressive variant of PCa and is the most common of the non-acinar subtypes [51] with a reported incidence of 0.5 6 % [52].
In summary, plasmacytoid variant of urothelial carcinoma is an aggressive variant associated with poor prognosis that presents at an advanced clinical stage.
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