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This point is even more important when we consider that ATC is a locally aggressive type of thyroid tumor with high rate of distant metastases.
The mutation acts both as a gain and loss of function mutant in thyroid cancer and determines thyroid tumor differentiation; in more aggressive tumors gain of function predominates [ 93].
On the basis of our in vitro results, we predicted that the three drug combination would result in tumor apoptosis in an 8505c thyroid orthotopic model of aggressive thyroid cancer with wide spread lung metastases.
Got a Thyroid Tumor?
Ken Kitty, a 13-year-old female, had an operation over the summer to remove a thyroid tumor, but a month later, the tumor began growing again.
Hyalinizing trabecular adenoma--an uncommon thyroid tumor frequently misdiagnosed as papillary or medullary thyroid carcinoma.
Aggressive thyroid cancers remain resistant to traditional chemotherapeutic agents.
Furthermore, UHRF1 and ITIH5 have a potential therapeutic/prognostic value for aggressive thyroid tumours.
Moreover, chemotherapeutic treatment proved to be largely ineffective against aggressive thyroid carcinomas [ 8].
Human thyroid tumor tissues and their normal counterparts were accumulated between 2006 and 2007 from patients with thyroid tumors.
To test the possibility that ABI3 expression is associated with thyroid tumor malignancy, we examined mRNA expression in a panel of thyroid tumors specimens and normal thyroid.
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