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In the present study, RASFs expressed high levels of sPLA2V, which promoted the aggressive properties of RASFs.
Digestion of extracellular matrix is both a major event during cell invasion and an indication of aggressive properties of cancer cells.
To examine whether sPLA2V regulates the aggressive properties of RASFs, cell viability and cartilage degradation were examined after transfection with sPLA2V siRNA.
To investigate whether sPLA2V-associated aggressive properties of RASFs are mediated by EPCR, RASFs were transfected with EPCR siRNA and stimulated with recombinant sPLA2V.
Consistent with these observations, our MUC4 knockdown experiments reveal that its expression contributes to the aggressive properties of breast tumor cells.
As 35 out of these 37 patients also had LN metastases, it is likely that the aggressive properties of LN metastases affected patients' prognoses more than did primary lesions.
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Another aggressive property of RASFs is their elevated migratory/invasive capacity.
Our finding indicates that FOXF2 may play a role in controlling the differentiation state of basal-like breast cells and inhibits the aggressive property of BLBC.
TWIST1 was negatively regulated by FOXF2 and mediated the FOXF2-regulated EMT phenotype of basal-like breast cells and aggressive property of BLBC.
Hence, our study provides for the first time, the importance of MUC4 in gastric cancer and explains the possible mechanism through which MUC4 can promote aggressive property of poorly differentiated gastric non-SRCC cells.
A number of studies have demonstrated the anti-aggressive properties of clozapine in schizophrenia and its positive effect in borderline personality disorder.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com