Unlike typical fissures, these seem to be secondary to the direct ulceration caused by the disease process rather than the increased internal sphincter pressure; they can be locally aggressive, progressing to form deep ulcers with granulating bases and overhanging skin edges.
We know what transgress, aggressive and progress mean.
"A child that is poorly brought up will become aggressive and progress to other behaviors," Dr. Reisberg said.
Now, the government must make aggressive, concrete progress or it is potentially setting itself up for a significant popular backlash.
Early onset is associated with a more aggressive, rapidly progressing disease, especially if symptoms appear before 40 years of age [ 16].
In particular, R6/2 mice (with approx. 150 CAG repeats) manifest a very aggressive, rapidly progressing form of HD, similar to the juvenile form in humans.
Because the aggressive infection progressed so rapidly that multiple ulcers resistant to the combined therapy presented one after another, M. ulcerans infection was also suspected.
However, despite an initial 12 18 months of regression, patients frequently relapse and a more aggressive cancer progresses to a castrate resistant status [ 4].
Conversely aggressive, rapidly progressing cancers are more likely to reach the threshold for clinical detection before a patient presents for screening or in the interval between routine screens and will therefore be reduced in a screen detected cancer cohort.
