Nevertheless, sub-group analyses revealed an association between rs2228570 (FokI) and absence of childhood sunburns (OR = 0.65, p = 0.003), between the 3'utr SNP rs739837 (BglI) and fair skin (OR = 1.31, p = 0.048), and between the promoter SNP rs4516035 and the more aggressive tumour location in head-neck and trunk (OR = 1.54, p = 0.020).
In contrast to other solid tumors, glioma presents various therapeutic challenges that include its intracranial location, aggressive biological behavior and infiltrative growth.
Individual grey reef sharks at Enewetak become highly aggressive at specific locations, suggesting they may exhibit dominant behavior over other sharks in their home areas.
The location of aggressive encounters in the zones of territory overlap (Figure S3), is also indicative of inter-, rathan than intra-, group dynamics [36], [76].
KIT exon 9 mutations are associated with a nongastric location, clinicopathologically aggressive features, and hyposensitivity to imatinib.
Furthermore, PLS are inherently aggressive tumors regardless of location, and nearly one third of PLS samples were AXL positive.
Even though the final diagnosis determined that the nodule was nonmalignant, its anatomic location required aggressive surgical intervention to remove it.
Analyses of chromosomal copy number aberrations (CNAs) have been proposed as a critical indicator of the possible location of aggressive cancer phenotype related genes [ 4, 5].
The rare hepatoid carcinoma of the biliary tree may mimic Klatskin-type cholangiocarcinoma with its shared clinical features such as old age, anatomic location, and aggressive behavior.
