Specifically, boys in the combined aggressive cluster had more social problems, displayed more aggression, and anger, more often met criteria for CD and SUD, reported higher levels of psychopathic traits, and committed more violent and other types of offenses than boys in the other two clusters and effect sizes (ES) indicated that most of these differences were large.
Overly aggressive clustering can minimize the false-positives, but may also lead to underestimation of the DNA copies and lower sensitivity.
We did not perform more aggressive clustering to avoid removing biologically relevant variation from alternative splicing or closely related members of gene families.
In order to identify those probes whose DNA methylation status characterized the epigenetic clustering based on βN, i.e. those showing significant differences between the most aggressive Cluster B1 and the least-aggressive Cluster A, Welch's t test was performed.
Some exceptions are made for barcodes with a single reads and barcodes that are not of the expected length, allowing for more aggressive clustering of these barcodes with other barcodes.
In a second step, a non-redundant gene list was generated (from the original UCSC Gene list) using an aggressive clustering strategy, which groups all transcripts that directly or indirectly (through other transcripts) overlap on the same strand of the same chromosome.
To obtain the most relevant data subsets with the necessary homogeneity, we selected their cluster of highly aggressive adenocarcinomas (cluster C2 of their cluster analysis) for our study.
"Momentum," the piano work she had just played on the program, seemed touched by all those influences, with its frenetic pace, Cuban dance rhythms and aggressive atonal cluster chords.
Lung cancer, malignant melanoma, and central nervous system astrocytoma grade IV, all aggressive cancers, cluster tightly.
In addition to this, I have given a characterization of the level of false negatives in the second half of the Discussion, which further illustrates the aggressive subdivision of clusters.
