The phrase "aggregation to the normal" is not standard in written English and may cause confusion.
It could be used in a specific context related to data analysis or statistics, but clarity is essential.
Example: "The aggregation to the normal distribution was necessary for accurate results in the study."
Alternatives: "convergence to the mean" or "collection towards the average".
23, 24 Thus, an agent designed to prevent aggregation should elevate Aβ42 CSF levels to the normal range, unless the therapeutic agent acts both to prevent aggregation and to increase clearance or degradation.
Prion diseases are fatal neurodegenerative disorders characterized by misfolding and aggregation of the normal prion protein PrPC.
Moreover, aggregation of the normal protein has been observed in rat hypothalamus neurons (Berciano et al, 2004).
Although we did not observe any difference in aggregation within the normal physiological range of extracellular calcium concentrations (0·5 2 mmol/l) (three donors, data not shown), results from this study demonstrate the impact of variable ectonucleotidase activity on platelet function, which may have profound implications in certain clinical conditions.
This would allow the non-HD allele to continue to make the normal protein and prevent the harmful protein aggregations that form from the HD protein.
While aggregated α-syn oligomers are neurotoxic (Rockenstein et al., 2014), α-syn tetramers are suggested to be the normal aggregation resistant conformation of the protein (Bartels et al., 2011; Wang et al., 2011), possibly explaining the tetramer abundance in Ifnb +/+ mice.
Although it is difficult to determine the "normal" extent of aggregation in human circulation due to how aggregation is assessed (predominantly ex vivo), enhanced RBC aggregation has been observed in a variety of disorders [ 5].
Basal normoglycemia, induced with either ultralente insulin or chlorpropamide, was associated with a significant reduction of the enhanced platelet aggregation rates to normal.
For example, an absent aggregation to all agonists with a normal response to ristocetin indicates Glanzmann thrombasthenia.
In diffuse plaques, aggregations of Aβ exists as nonamyloid deposits, but as the plaque progresses, the Aβ and other protein aggregations change from the normal conformation into a β-sheet structure, termed amyloid, and take up specific dyes like Congo red and thioflavin [ 4].
