Sentence examples for aggregation or accumulation from inspiring English sources

Most current Alzheimer's disease (AD) therapies in advanced phases of development target amyloid β-peptide (Aβ) production, aggregation, or accumulation.

All five models show SNCA aggregation or accumulation in the brain, as well as other PD-related phenotypes (Magen and Chesselet, 2010).

Taking into account that gold nanoparticle aggregation or accumulation causes a broadening and red-shift in the absorption spectrum [ 40], we expect that the cell damage threshold can further be decreased by using longer laser wavelengths.

In the absence of NLS-biotin, no detectable import of SAv-Cy5 into the nucleus was detected over 30 min. Careful examination of the confocal images did not show signs of aggregation or accumulation processes of SAv-Cy5 within specific nuclear domains (Fig. 1 and Fig. S1).

In addition, we did not see accumulation or aggregation near openings of dispensers containing only 2 mM sodium phosphate (pH 8.0), 5 mM KCl, or 2 mM KOH, indicating that cyanide ion, and not buffer or potassium ions or elevated pH, was responsible for the attraction.

Instead, researchers have hypothesized that Aβ, tau, and α-syn might promote the accumulation or aggregation of one another [ 17, 18].

Low levels of gp150 are observed at mid-aggregation, and accumulation occurs during mound formation [ 29].

Many of the new experimental therapies for AD attempt to prevent the formation, aggregation, and accumulation or the facilitation of A β removal from preexisting deposits.

We observed alpha-synuclein aggregation only in the larger accumulations identified in mice treated for 3 months (Figure 1D).

However, attractive therapeutic approaches are based on the idea of smoothing the protein landscape to prevent accumulation of aggregation-prone or toxic species.

Accumulation of aggregation-prone proteins is involved in neurodegeneration.