The phrase "aggregation of substrate" is correct and usable in written English.
It can be used in contexts related to biology, chemistry, or materials science, where you are discussing the collection or grouping of substrates.
Example: "The aggregation of substrate in the reaction vessel facilitated the formation of the desired compound."
Alternatives: "collection of substrate" or "grouping of substrate".
Both diseases arise because lysosomal dysfunction leads to excessive aggregation of substrates that normally are degraded.
It is this cycle of rapid but controlled binding and release of the substrate that fosters folding and assembly with partner proteins while preventing aggregation of substrates [ 29].
As disruption in dynein-dependent transport is implicated in the cause of this group of diseases, it is likely that the aggregation of substrates seen in mouse models could, at least, in part result from the disruption of the microtubule-dependent movement of autophagosomes, autophagosome maturation, and autophagosome lysosome fusion.
Experimental conditions must then be precisely established in order to carry out studies where the precise state of aggregation of the substrate is known so the physicochemical properties which characterize the protein Casiopeína III-ia complex (formation constant, formation enthalpy, stoichiometry, etc).
However, when an equimolar ratio of mtHsp70/J-protein (hTid-1S) was equilibrated to allow complex formation, followed by addition of rhodanese, wild-type mtHsp70 robustly prevented the aggregation of model substrate when compared with BSA control (Fig. 2C).
According to the comparison between graphdiyne and graphene, it was found that the high adsorption ability of graphdiyne can avoid Pt nanoparticle migration and aggregation on substrate.
Further, it was found that 14-3-3 cas aconventionalentional chaperone preventing aggregation of protein substrates or even by dissolving preformed aggregates.
The ability of Skp to prevent the aggregation of model substrates in vitro is independent of ATP.
To further test the requirement of K63 linkage in the aggregation of proteasome substrates, we transfected additional ubiquitin mutants tagged to HA (hemagglutinin) in SH-SY5Y cells that stably expressed GFP-ubiquitin.
As a chaperone, VCP prevents aggregation of UPS substrates prior to their presentation to the proteasome [ 118, 138].
