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Further, it was found that 14-3-3 cas aconventionalentional chaperone preventing aggregation of protein substrates or even by dissolving preformed aggregates.
Aggregation of protein biotherapeutics has consequences for decreasing production and has been implicated in immunogenicity.
Conclusion: Among all the tested excipients, 100 mM of arginine inhibited the aggregation of protein during radiolabeling.
In low shear regions of the eccentric cell (wider gap settings), reformation or aggregation of protein domains was observed.
Increasing the ionic strength of the aqueous phase resulted in enhanced peak currents, possibly due to aggregation of protein precipitates in the aqueous solution.
The abnormal aggregation of protein within the cytoplasm or the nucleus of brain cells represents a unifying pathological feature of these diseases.
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We propose that these changes increase the propensity of γD-crystallin to self-aggregate and contribute to the aggregation of proteins that occurs in aging and cataractous lenses.
The aggregation of proteins often results in highly ordered fibrillar structures.
A pathological hallmark of many neurodegenerative diseases is the aggregation of proteins.
We study the effect of helical structure on the aggregation of proteins using a simplified lattice protein model with an implicit membrane environment.
When SEC is used, aggregation of proteins and EVs is minimal [40, 75], and the function of EVs is usually unaffected.
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