Studies of experimental models of AD and in human brain support the notion that aggregation of Aβ, resulting in the formation of toxic oligomers rather than fibrils, might be ultimately responsible for the synaptic damage that leads to cognitive dysfunction in patients with AD (Walsh and Selkoe 2004; Glabe 2005; Glabe and Kayed 2006; Fig. 1).
During the past decade, hypotheses concerning the pathogenesis of most neurodegenerative diseases have been dominated by the notion that the aggregation of specific proteins and subsequent formation of cytoplasmic and extracellular lesions represent a harbinger of neuronal dysfunction and death.
We reported geographic variations of gout prevalence and incidence and attribute the significantly higher prevalence and incidence in the eastern coastal areas and offshore islets to aggregation of aboriginals; however, we do not have ethnicity data to support this notion.
These results supported the notion that hydrogen bonding played a key role in the aggregation of compound 2, which could simulate the hydrogen bonding interaction in the aggregation behavior of asphaltenes.
Such a tradition would contain its own refutation, for it involves the notion of the construction of a body politic by the aggregation of families into unities, and by further combinations of these new unities.
Taking that notion further, we contemplate that the early event in AD pathology might be the aggregation of intracellular Aβ in response to an increase in [Ca2+]i as a result of natural aging processes.
The aggregation of research suggests that AR, asthma, and chronic rhinosinusitis are linked by the united allergic airway, a notion that encompasses commonalities in pathophysiology, epidemiology, and treatment.
The aggregation of research suggests that AR and asthma are, in fact, one syndrome in two parts of the respiratory tract this notion is supported pathophysiologically, epidemiologically, and through numerous clinical studies.
Aggregation of cartilage proteoglycans.
Politics is driven by aggregation of power and privilege.
Sellers would get a better price, through aggregation of demand.
