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The effect of the environment might be even more pronounced in patients whose phenotypes are caused by the aggregation of small contributions from many genetic and non-genetic factors.
Since PSA regulates overall aggregation mediated from exon 1 of huntingtin in an autophagy-dependent manner, any contribution towards aggregation of PSA acting as an aminopeptidase on isolated expanded polyQ tracts derived from larger huntingtin fragments will be very minor.
The contribution of the aggregation of the silver nanoparticle film into compact bulk silver material [16] is promoting the reaction of the –SO3 − group on the PDMS surface with more Ag+ dangling bonds and thus the formation of more and stronger chemical bonds between –SO3 − and Ag+.
This very strong familial aggregation of insulin resistance suggests a strong contribution of environmental factors.
The observation that proline substitutions outside the putative core domain effectively abolish amyloid formation indicates that models of IAPP aggregation must consider contributions from other regions.
Open your list of contributions.
Accumulating evidence supports a prominent contribution of misfolding and aggregation of SOD1 to the dysfunction and progressive death of motor neurons in ALS.
Early and more recent investigations [ 8, 9] show significant maternal familial aggregation of high blood pressure, which suggests a contribution of the mitochondrial genome to hypertension [ 10].
Besides assessing life-style factors and cancer risks, they can point to the environmental contribution to the familial aggregation of cancer, and they thus help to apportion heritable effects (Hemminki et al, 2001a, d).
Generalized estimating equations were used to examine the familial aggregation of panic and social anxiety disorders, and the contributions of comorbid disorders.
To examine familial aggregation of gout and to estimate the heritability and environmental contributions to gout susceptibility in the general population.
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