Similar to the oxidative hypothesis raised above, this suggested that fragmentation and/or aggregation generates SR-A ligands from apo A-I.
According to previous studies from our laboratory, ribosylation promotes proteins to form aggregation, generates cytotoxic AG Es decreases cell viability of HEK293T and SH-SY5Y cells, and thus might result in direct damage to the nervous system.
Multiple protein complexes with BAG3, wild type αB-crystallin, HspB8 and Hsp70 may cooperatively inhibit protein aggregation generated by mutations in αB-crystallin.
To further confirm these findings we also characterized the morphology of the three AT3 variants by AFM, which actually showed that AT3Q55 underwent progressive aggregation, generating oligomers (Fig. 6A), which formed clusters after 24 h (Fig. 6B) and gave rise to bundles of tangled SDS-resistant fibrils at 48 and 72 h (Fig. 6C and D).
In the present paper, we show that CX3CL1, which is endowed with only one TM domain, has a lateral diffusion that is slower than that of the CX3CR1, which, similarly to all GPCRs, is a 7-TM molecule, and we demonstrate that this slow diffusivity is due to the glycosylation of the mucin stalk and the aggregation generated by the TM domain.
For the concentration at which H1.4 causes aggregation, no aggregation was generated by mutants lacking the C-terminal domain.
By acetylating cyclooxygenase, aspirin inhibits platelet aggregation and generates anti-inflammatory molecules which modulate neutrophilic inflammation [4].
Yeast flocculation is defined as an asexual and reversible Ca2+-dependent cellular aggregation that generates fast-sedimenting flocs containing high numbers of yeast cells (Bony et al. [1997]; Stratford, [1989]).
To further characterize the effects of the combinatory use of Bicalutamide and trehalose, their activity was also tested on a form of AR containing a very long polyQ (Q112) tract, which has a different kinetic of aggregation and generates nuclear inclusions.
For dynamic measurement of FUS mislocalization, DNA recruitment and protein aggregation we generated isogenic iPSC lines with GFP-tags of the endogenous FUS protein using CRISPR/Cas9n.
In vitro and in vivo studies have suggested that metal binding to Aβ could facilitate Aβ aggregation and generate reactive oxygen species (ROS), which could contribute to the neuropathogenesis of AD.
